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| First Name: | Nicole | | Last Name: | Schupf | | Advanced Degrees: | Ph.D., Dr.P.H. | | Affiliation: | Columbia University | | Department: | Taub Institute for Research on ALzheimer's disease and the AGing Brain | | Street Address 1: | PO Box 16 | | Street Address 2: | 630 West 168th Street | | City: | New York | | State/Province: | NY | | Zip/Postal Code: | 10032 | Country/Territory: | U.S.A. | | Phone: | (212) 305-2381 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 14 September 2005]
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Neurodevelopmental Disorders (Down syndrome, etc.), Alzheimer Disease
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Genetics, A-beta PP/A-beta, Epidemiology
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Nicole Schupf studies aging and Alzheimer's disease in adults with Down syndrome. Virtually all individuals with Down syndrome have key the neuropathological changes consistent with AD by the time they reach 40 years of age, but age at onset of AD varies widely, and not all adults with Down syndrome develop dementia. Identification of factors that influence when and whether adults with Down syndrome develop AD may serve as a model for the development of AD. Current research focuses on the influence of hormone-related polymorphisms on plasma levels of beta amyloid peptides and risk of AD.
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N. Schupf, D. Kapell, J.H. Lee, R. Ottman and R. Mayeux (1994) Increased risk of Alzheimer's disease in mothers of adults with Down syndrome. Lancet 334:353-356.
N. Schupf, D. Kapell, W. Zigman, B. Canto, B. Tycko and R. Mayeux. (1996). Onset of dementia and decline in adaptive competence is associated with apolipoprotein E e4 in Down syndrome. Annals of Neurology 40:799-801.
N. Schupf, W. Zigman, D. Kapell, J.H. Lee, J. Kline and B. Levin (1997). Early menopause in women with Down syndrome. Journal of Intellectual Disability Research 41:264-267 .
N. Schupf, B. Patel, W. Silverman, W. Zigman, N. Zhong, B. Tycko, P. Mehta, R. Mayeux (2001). Elevated Plasma Amyloid b-peptide 1-42 and onset of dementia in Down syndrome. Neuroscience Letters 301:199-203
N. Schupf, D. Kapell, B. Nightingale, J.H Lee, J. Mohlenhoff, S. Bewley, R. Ottman, R. Mayeux (2001). Specificity of the five-fold increase in AD in mothers of adults with Down syndrome Neurology 57:979-984.
N. Schupf (2002) Genetic and host factors for dementia in Down syndrome. British Journal of Psychiatry 180:405-410
N. Schupf, D. Pang, BN Patel, W. Silverman, R. Schubert, F. Lai, JK Kline, Y Stern, M. Ferin, B. Tycko, R. Mayeux (2003). Onset of dementia is associated with age at menopause in women with Down syndrome. Annals of Neurology 54:433-438.
N. Schupf, R. Costa, M-X Tang, H. Andrews, B. Tycko, R. Mayeux (2004). Preservation of cognitive and functional ability as markers of family longevity. Neurobiology of Aging 25 (9):1231-1240.
N. Schupf, R. Costa, J. Luchsinger, M-X Tang, JH Lee, R Mayeux (2005). Relation of plasma lipids to all-cause mortality in nondemented elderly. Journal of the American Geriatric Society. 53(2):219-229
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